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16
Dec
Calculating the number of effective checks using SimpleM

Calculating the number of effective checks using SimpleM

什么是 SimpleM? 在 GWAS(全基因组关联研究)中,我们通常需要对数百万个单核苷酸多态性(SNPs)进行假设检验,从而发现与目标表型相关的遗传变异。然而,这种大规模的多重检验问题容易导致假阳性,因此需要对显著性水平进行矫正(如 Bonferroni 矫正)。 In GWAS (genome-wide association
7 min read
03
Sep
Whole-genome re-sequencing reveals genetic structure and selection signals of different populations in Megalobrama amblycephala

Whole-genome re-sequencing reveals genetic structure and selection signals of different populations in Megalobrama amblycephala

Abstract Characterization of genetic variants is crucial for understanding the molecular mechanisms behind selected traits and enhancing the rate of
4 min read